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December 31, 2020

Five weight-loss questions I’m asked all the time: obesity researcher Dr Nick Fuller

Filed under: Fitness — Tags: — admin @ 11:12 pm

Dr Nick Fuller has described weight loss as a “cultural obsession” — yet despite that obsession, most of us struggle to lose weight then keep it off.

Two-thirds of Australian adults and a quarter of Australian children are overweight or obese, and the numbers are climbing despite the literally thousands of diet books and weight-loss how-tos on the market.

Fuller, an obesity researcher at the University of Sydney, argues there’s a straightforward reason for that: traditional dieting fights against human biology, which is why it’s “doomed from the start”. He advocates a different method: interval weight loss, outlined in his book of the same name and its follow-up.

These are five of the weight-loss questions he’s asked most often.

I can’t lose weight because I have bad genes or I’m big boned. What do I do?

Our genes have not changed over time and they are not the reason for the increase in waistlines we see today. Genes contribute less than 3 percemt of the prevalence of obesity and regardless of what genes you think you have, you can lose weight just as easy as the person next to you.

Interval Weight Loss for Life
(Supplied)

However, years or decades of abuse on the body, in the form of dieting, will see it slow down — sluggish metabolism — and consequently your body will become very good at defending itself against weight loss. So you can blame your previous diet attempts, but you can’t blame your genes.

How do I lose 5kg by next week?

That’s the easy part. Any of those crazy diets, especially any sort of fast or detox where you starve yourself of nutrition, will result in the 5kg weight loss in a week. But the week after will only see you stacking 6 kg back on.

As soon as you lose weight, your body will start to work differently to defend its “set point” – the weight you will remember being at for a long period of time.

We have discovered through our research that there are a range of biological protections that kick into gear when you impose a stress on the body, such as dieting, so despite all your good intentions, you are doomed for failure the minute you begin.

The only way to overcome these biological protections and prevent your metabolism lowering and your appetite hormones changing telling you to eat more, is to follow an evidence-based Interval Weight Loss plan. This plan gets a person to impose diet breaks along the way, to ensure their body adjusts to the new lowered set point at intervals along the way.

Which diet is better – keto, 5:2, Atkins, or paleo?

There is a reason why all of these diets have been objectively ranked in the bottom 10 diets for both 2018 and 2019 in the US News and World Report – they lack the science to support their bold claims and they aren’t safe or nutritionally balanced.

We all hear of people’s short-term successes on diets, but these same people never talk about the long-term result where they end up fatter than before they began. No diets address our “set point” – the weight our biology will always protect.

Worse still, by following these diets you are putting yourself at serious long-term health risk — for example, cutting whole grain carbs will increase your risk of colon cancer, type 2 diabetes and heart disease.

Isn’t fruit bad for me because it contains sugar?

The whole sugar-free message is confusing and not based on scientific evidence — it’s all “anecdata”.

Dr Nick Fuller
Dr Nick Fuller (Supplied )

Generally speaking, advocates for sugar-free diets say to avoid table sugar, some natural sweeteners like maple syrup and honey, sweets, condiments, soft drinks and a selection of fruits — an arbitrary list of foods to avoid which has no substance to its claim.

Many of these foods that are blacklisted on sugar-free diets contain naturally occurring sugars, such as fruit. These foods are protective for our health — they prevent heart disease, type 2 diabetes and cancer, and should be part of your daily eating plan.

So, despite what you’ve been told, bananas, potatoes or any variety of fruits or vegetables won’t make you fat. They are key weapons in your weight-loss arsenal.

Is organic better for my health?

Don’t waste your time with anything labelled “organic”.

Organic farmers and food producers are supposed to grow food without using synthetic chemicals such as pesticides and artificial fertilisers. But, as a matter of fact, there is no regulation on the use of the word “organic” in Australia. Anyone can slap the term on their food and you just have to trust the seller that they’re not telling you little white lies. Even packaged foods such as muesli bars can have ‘organic’ on their labelling but mislead you by containing both ‘organic’ and ‘natural’ ingredients.

Organic food is double the price point of conventional produce, so save yourself the cost and focus on just including more fruit and vegetables in your eating plan. The only way to know you’re buying organic is by getting a food that is “certified organic” – these companies have paid to have their foods tested by a third party.

Go here for more questions health experts are asked all the time.

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Traditional Ghanaian medicines show promise against tropical diseases

Filed under: Health — admin @ 7:38 pm

The discovery of new drugs is vital to achieving the eradication of neglected tropical diseases (NTDs) in Africa and around the world. Now, researchers reporting in PLOS Neglected Tropical Diseases have identified traditional Ghanaian medicines which work in the lab against schistosomiasis, onchocerciasis and lymphatic filariasis, three diseases endemic to Ghana.

The major intervention for NTDs in Ghana is currently mass drug administration of a few repeatedly recycled drugs, which can lead to reduced efficacy and the emergence of drug resistance. Chronic infections of schistosomiasis, onchocerciasis and lymphatic filariasis can be fatal. Schistosomiasis is caused by the blood flukes Schistosome haematobium and S. mansoni. Onchocerciasis, or river blindness, is caused by the parasitic worm Onchocerca volvulus. Lymphatic filariasis, also called elephantiasis, is caused by the parasitic filarial worm Wuchereria bancrofti.

In the new work, Dorcas Osei-Safo of the University of Ghana, and colleagues obtained — from the Ghana Federation of Traditional Medicines Practitioners Association — 15 traditional medicines used for treating NTDs in local communities. The medicines were available in aqueous herbal preparations or dried powdered herbs. In all cases, crude extracts were prepared from the herbs and screened in the laboratory for their ability to treat various NTDs.

Two extracts, NTD-B4-DCM and NTD-B7-DCM, displayed high activity against S. mansoni adult worms, decreasing the movement of the worms by 78.4% and 84.3% respectively. A different extract, NTD-B2-DCM, was the most active against adult Onchocera onchengi worms, killing 100% of males and more than 60% of females. Eight of 26 crude extracts tested, including NTD-B4-DCM and NTD-B2-DCM, also exhibited good activity against trypanosomes — parasites that cause other human diseases but weren’t the original targets of the traditional medicines.

“By embracing indigenous knowledge systems which have evolved over centuries, we can potentially unlock a wealth of untapped research and shape it by conducting sound scientific investigations to produce safe, efficacious and good quality remedies,” the researchers say.

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Materials provided by PLOS. Note: Content may be edited for style and length.

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Multiple mosquito blood meals accelerate malaria transmission

Filed under: Health — admin @ 7:14 pm

Multiple bouts of blood feeding by mosquitoes shorten the incubation period for malaria parasites and increase malaria transmission potential, according to a study published December 31 in the open-access journal PLOS Pathogens by Lauren Childs of Virginia Tech, Flaminia Catteruccia of the Harvard T.H. Chan School of Public Health, and colleagues. Given that mosquitoes feed on blood multiple times in natural settings, the results suggest that malaria elimination may be substantially more challenging than suggested by previous experiments, which typically involve a single blood meal.

Malaria remains a devastating disease for tropical and subtropical regions, accounting for an estimated 405,000 deaths and 228 million cases in 2018. In natural settings, the female Anopheles gambiae mosquito — the major malaria vector — feeds on blood multiple times in her lifespan. Such complex behavior is regularly overlooked when mosquitoes are experimentally infected with malaria parasites, limiting our ability to accurately describe potential effects on transmission. In the new study, the researchers examine how additional blood feeding affects the development and transmission potential of Plasmodium falciparum malaria parasites in An. gambiae females.

“We wanted to capture the fact that, in endemic regions, malaria-transmitting mosquitoes are feeding on blood roughly every 2-3 days,” says W. Robert Shaw, a lead author of this study. “Our study shows that this natural behavior strongly promotes the transmission potential of malaria parasites, in previously unappreciated ways.”

The results show that an additional blood feed three days after infection with P. falciparum accelerates the growth of the malaria parasite, thereby shortening the incubation period required before transmission to humans can occur. Incorporating these data into a mathematical model across sub-Saharan Africa reveals that malaria transmission potential is likely higher than previously thought, making disease elimination more difficult. In addition, parasite growth is accelerated in genetically modified mosquitoes with reduced reproductive capacity, suggesting that control strategies using this approach, with the aim of suppressing Anopheles populations, may inadvertently favor malaria transmission. The data also suggest that parasites can be transmitted by younger mosquitoes, which are less susceptible to insecticide killing, with negative implications for the success of insecticide-based strategies. Taken together, the results suggest that younger mosquitoes and those with reduced reproductive ability may provide a larger contribution to infection than previously thought.

According to the authors, the findings have important implications for accurately understanding malaria transmission potential and estimating the true impact of current and future mosquito control measures.

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Materials provided by PLOS. Note: Content may be edited for style and length.

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New virtual screening strategy identifies existing drug that inhibits COVID-19 virus

Filed under: Health — admin @ 7:14 pm

A novel computational drug screening strategy combined with lab experiments suggest that pralatrexate, a chemotherapy medication originally developed to treat lymphoma, could potentially be repurposed to treat Covid-19. Haiping Zhang of the Shenzhen Institutes of Advanced Technology in Shenzhen, China, and colleagues present these findings in the open-access journal PLOS Computational Biology.

With the Covid-19 pandemic causing illness and death worldwide, better treatments are urgently needed. One shortcut could be to repurpose existing drugs that were originally developed to treat other conditions. Computational methods can help identify such drugs by simulating how different drugs would interact with SARS-CoV-2, the virus that causes Covid-19.

To aid virtual screening of existing drugs, Zhang and colleagues combined multiple computational techniques that simulate drug-virus interactions from different, complimentary perspectives. They used this hybrid approach to screen 1,906 existing drugs for their potential ability to inhibit replication of SARS-CoV-2 by targeting a viral protein called RNA-dependent RNA polymerase (RdRP).

The novel screening approach identified four promising drugs, which were then tested against SARS-CoV-2 in lab experiments. Two of the drugs, pralatrexate and azithromycin, successfully inhibited replication of the virus. Further lab experiments showed that pralatrexate more strongly inhibited viral replication than did remdesivir, a drug that is currently used to treat some Covid-19 patients.

These findings suggest that pralatrexate could potentially be repurposed to treat Covid-19. However, this chemotherapy drug can prompt significant side effects and is used for people with terminal lymphoma, so immediate use for Covid-19 patients is not guaranteed. Still, the findings support the use of the new screening strategy to identify drugs that could be repurposed.

“We have demonstrated the value of our novel hybrid approach that combines deep-learning technologies with more traditional simulations of molecular dynamics,” Zhang says. He and his colleagues are now developing additional computational methods for generating novel molecular structures that could be developed into new drugs to treat Covid-19.

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Materials provided by PLOS. Note: Content may be edited for style and length.

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‘Damn’: Brutal war ended in savage KODaigo Higa knocked Yuki Strong Kobayashi into last week.

Filed under: Outdoors — admin @ 3:40 pm

Kazuto Ioka has retained his WBO super flyweight title in an absolute war with Kosei Tanaka in the final title fight of the year.

The pair slugged it out but the 31-year-old Ioka showed just why he is the champ having won in an eighth round TKO as he knocked Tanaka out on his feet.

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Tanaka had been knocked down twice before in the fifth and sixth round but a massive left hook left the challenger in la la land as Ioka defended his title for the second time.

Both men came into the fight as world title winners at multiple weights with the 25-year-old Tanaka fighting to become the fastest fighter to win four weight divisions have held the WBO mini-flyweight title from 2015 to 2016, the WBO junior-flyweight title from 2016 to 2017 and the WBO flyweight title.

Incredibly, he still has seven more fights to beat Oscar de la Hoya’s record but his 15-0 record now has its first loss.

Tanaka was a massive favourite in the fight but despite both men copping punishment, it was Ioka who withstood best, with three brutal knockdowns from left hooks giving him the belt.

Ioka for the knockout was at 6-1 odds according to Fox boxing reporter Mike Ortega which was stunning for the defending champ.

Ioka has trod the ground ahead of Tanaka, having won the mini-flyweight, light-flyweight, flyweight and super flyweight titles.

It appeared an even fight to start off with both men dishing out punishment, but late in the fifth, Ioka hit Tanaka with a right before coming over the top with what the commentator called “a picture perfect” left hook that floored the challenger.

In the sixth, another left hook left Tanaka on the canvas again as he went looking for the KO as Ioka smelled blood.

With his back against the wall, Tanaka came out swinging to finish the round.

He swung until the end with Ioka waiting for the right time before his left knock Tanaka out only to be caught by the referee.

Social media was impressed by both men as the slugged out the fight.

In the co-main event on the tight card, Daigo Higa claimed a fifth round KO against Yuki Strong Kobayashi.

As the former flyweight champion, Higa is attempting to comeback at bantamweight has his victory will place the division on notice as he savagely dispatched Kobayashi.

Higa was throwing bombs from the outset as he landed some huge uppercuts in the third round to take control of the fight.

The uppercuts kept going with Kobayashi’s legs giving out as he collapsed.

Although he tried to get to his feet, blood poured from his nose and his corner rushed to his aid and treated him on the canvas.

“As brutal an uppercut knockout as you’re going to see,” the commentator said.

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Beer then wine won’t make you fine: Why you feel rubbish after mixing drinks

Filed under: Fitness — Tags: — admin @ 12:12 am

Why does bouncing from beer to wine to spirits seem to cause worse hangovers than just sticking with one?

Plenty of people put a throbbing hangover down to the fact they switched from beer to spirits or wine to cocktails, and assume there’s some kind of complex chemistry going on in our bodies that punishes us for switching between alcoholic varieties.

Sure, experts say that working your way through a bar’s extensive drinks list will make you more hungover. But it’s not because of the variety of drinks you consumed – it’s purely the volume.

“It’s very hard to mix one drink, so when people are mixing drinks they are usually drinking more,” Professor Steve Allsop, director of Curtin University’s National Drug Research Institute, told Coach.

“If you had half a glass of red wine and half a glass of white wine or a small glass of beer and a small whisky, that’s mixing drinks but it’s not likely to cause a hangover as much as when you have half a dozen drinks of one thing and then add something else.”

RELATED: The amazing gains your body makes when you take a break from booze

Your behaviour in the lead-up and during a big alcohol night can play a role in how ill you feel the next day – particularly drinking on an empty stomach and not drinking enough water.

“Alcohol has a diuretic effect, which makes you need to urinate more frequently. If the only liquid you consume is alcoholic, you’ll become dehydrated, especially in warmer climates,” Professor Allsop writes on The Conversation.

“Heavy drinking also results in poor sleep. Alcohol is a soporific and many of us fall asleep more quickly after drinking. But we are less likely to get the quality rapid eye movement sleep required to wake feeling refreshed.”

If you think you get worse hangovers from red wine or bourbon, you might be right. They have higher levels of chemicals called congeners, which contribute to the taste and colour of a drink, and are believed to increase severity of a hangover.

Some people are also sensitive to certain preservatives or additives in drinks, which can make them feel off.

“If you find yourself particularly sensitive to certain types of beverages or certain brands, the simple advice is to stay away from those brands,” Professor Allsop says.

“It’s just like some people find they are sensitive to certain types of food.”

Ultimately Professor Allsop says that the biggest predictor of a bad hangover is how high your blood alcohol level gets.

“The peak blood alcohol that you reach seems to be particularly relevant,” he explains.

“If you drink a lot quickly on an empty stomach you may feel worse the next day than if you drink gradually with food over the course of an evening.”

People’s blood alcohol level tolerance will also vary depending on how often you drink.

“Most drugs – whether that be caffeine or tobacco or alcohol or any other drug – when we take them we build up a tolerance and that [means] you need to have more to have the same effect,” Professor Allsop explains.

That’s why people often report feeling particularly sensitive to alcohol after they have had a break, such as doing Dry July or through pregnancy.

Of course, some people report never getting hangovers, but Professor Allsop says that’s not necessarily cause for celebration.

“There is some suggestion that people who don’t get hangovers might be at greater risk of developing alcohol problems at a later stage because they don’t have an ‘off switch’,” he points out.

“Some people will think ‘I better stop now because I might feel pretty ordinary in the morning’, and that is probably a good thing because that’s saying, ‘You’ve had too much to drink mate, stop now’.”

RELATED: Booze on trial

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December 30, 2020

A Look Back at the Best Viral Videos From 2020

Filed under: Fitness — Tags: , , — admin @ 10:29 pm

For most of us, 2020 was a year we’d rather forget. But instead of solely focusing on the negative, let’s try to remember a few of the moments from the past 365 days that actually brought a smile to our faces.

Of course, the personal and intimate moments shared with friends and family––even during those awkward Zoom chats––were what mattered most. However, it’s also fun to remember some of those wild and wonky clips that kept us entertained. These are the clips that made us laugh, inspired us, shocked us and helped us as we made our way through this strange and trying year. And with most of us stuck inside and looking at our phones anyway, it was a banner year for viral videos.


 

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Scientists explore deficits in processing speed in individuals with spinal cord injury

Filed under: Health — admin @ 9:12 pm

A team of rehabilitation researchers has studied processing speed deficits in individuals with spinal cord injury (SCI), comparing their brain activation patterns with those of healthy age-matched controls, and older healthy individuals. They found that the SCI group and older controls had similar activation patterns, but the SCI group differed significantly from their age-matched controls.

The article, “The neural mechanisms underlying processing speed deficits in individuals who have sustained a spinal cord injury: A pilot study”  was published online on September 25, 2020 by Brain Topography. The authors are scientists with expertise in research in cognitive rehabilitation and SCI rehabilitation: Glenn Wylie, DPhil, Nancy D. Chiaravalloti, PhD, Erica Weber, PhD, Helen Genova, PhD, and Trevor Dyson-Hudson, MD, from Kessler Foundation, and Jill M. Wecht, EdD, from the James J. Peters VA Medical Center.

Individuals with chronic SCI have an increased risk for cognitive deficits that resemble the deficits associated with the aging process, giving rise to the theory of “accelerated cognitive aging.” As reported previously by this team, the deficits affect processing speed, new learning and memory, and verbal fluency, which are the domains affected during aging. This study is the first to examine the neural mechanisms of higher order cognitive tasks of individuals with SCI. The focus was on processing speed, which is known to be affected by SCI and aging, and is integral to cognitive function and everyday life activities.

The 30 participants were participants of a larger study who underwent optional neuroimaging studies at the Rocco Ortenzio Neuroimaging Center at Kessler Foundation — 10 individuals with cervical SCI, 10 age-matched controls, and 10 healthy older individuals. In addition to traditional neuropsychological testing methods, processing speed was tested in the scanner, using timed letter comparison tasks during functional magnetic resonance imaging (fMRI). This study was the first to use the modified letter comparison test.

Significant differences in brain activation were found between the SCI group and the age-matched control group, but the SCI and older groups had similar patterns, including activation of the hippocampal, frontal and parietal areas. “This suggests that individuals with SCI are compensating for deficits in processing speed by relying on the areas of the brain involved in executive control and memory,” noted Dr. Chiaravalloti, “which supports the theory of accelerated brain aging after SCI.”

Despite the limitations of sample size and level of injury, the study is an important contribution to our understanding of the impact of SCI on cognition, according to Dr. Wylie, director of the Ortenzio Center. “Our ability to observe brain activation while the individual performs specific cognitive tasks provides new information on the mechanisms that underlie the cognitive deficits that we now know affect a substantial proportion of the SCI population,” Dr. Wylie said. “Developing treatments targeted to these deficits depends on our pursuit of this line of research, which may benefit other populations affected by delayed processing speed.”

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Materials provided by Kessler Foundation. Note: Content may be edited for style and length.

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Five Minutes of Ridiculous Surfing Wipeouts and What Causes Them

Filed under: Fitness — Tags: , , , — admin @ 5:22 pm

Anyone who has ever entered the ocean and attempted to ride a wave has probably experienced it: The Wipeout. They range from gentle splashes to violent pounddowns that reduce you to a helpless rag doll. Regardless, the thrill of riding a good wave always outweighs the unfortunate experience of being dragged along the ocean floor.

In an ode to the wipeout, surfer Brad Jacobson walks us through the many different types of wipeouts and what mistake causes each one. Watching this video will not only provide some interesting insight into surfing technique, but it also is very entertaining. Because let’s face it, watching other people wipeout for five straight minutes is a great distraction from work, chores, or anything for that matter.


Sit back, relax, and enjoy.

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‘Extraordinary’ end to Big Bash thrillerThe final delivery at the Gabba.

Filed under: Outdoors — admin @ 3:34 pm

The Brisbane Heat have lost their Big Bash League fixture against the Hobart Hurricanes by the barest of margins, falling agonisingly short in their run chase at the Gabba.

Chasing 151 for victory on Wednesday evening, the Heat found themselves needing two runs from the final delivery to secure a win.

Hurricanes paceman Scott Boland delivered a low full toss, which Mark Steketee slapped into the covers and promptly sprinted through for a quick single.

It was stopped by South African international Colin Ingram, who struck the wickets at the non-striker’s end with a direct hit.

The decision went upstairs to the third umpire, and replays showed that Steketee’s bat had bounced as the stumps were dismantled.

The untimely bounce meant Steketee had been run out, and the Hurricanes had secured a nailbiting one-run victory.

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A chorus of boos echoed around the Gabba when the verdict appeared on the big screen and the baffled Hobart players celebrated in the middle.

“I spent the last two minutes trying to slow my heart rate and take a lot of deep breaths, because that was pretty extraordinary finish,” Hurricanes captain Peter Handscomb said on Fox Cricket after the match.

“To defend (15 runs) off those last two overs was pretty bloody awesome.

“I thought (Steketee) was in, didn’t know the bat was up in the air. But once we saw the replays, we were pretty happy.”

Former Australian Test bowler Trent Copeland tweeted: “Unbelievable run out to finish! Cracking game of cricket. BBL is delivering! Anyone can beat anyone. Last over finishes so often.”

Women’s T20 World Cup champion Megan Schutt posted: “Crazy good game of cricket.”

READ MORE: Veteran’s 4188-day first in dream return

Heat newcomer James Bazley finished with 49 not out off 31 balls, his classy knock featuring four boundaries and three sixes.

Hurricanes speedster Riley Meredith was the chief destroyer with the ball, claiming 3/21 from four overs.

He was supported by former Australian paceman Scott Boland, who only conceded 18 runs from his four-over spell.

Earlier, Afghan tweaker Mujeeb Ur Rahman claimed his maiden five-wicket haul in the T20 format to help restrict the Hurricanes to 150.

For their next fixture, Hobart will take on the Melbourne Stars at Blundstone Arena on Saturday afternoon.

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